ObjectiveTo investigate the clinical efficacy of AngioJet thrombectomy combined with iliac vein stenting for patients diagnosed with acute lower extremity deep venous thrombosis (DVT) with iliac vein compression. MethodsBetween January 2021 and October 2023, a total of 64 patients with acute lower extremity DVT which performed AngioJet thrombectomy combined with iliac vein stenting in Weifang People’s Hospital were retrospectively analyzed. The changes of clinical symptoms, signs, and thrombus burden between pre- and postsurgically were observed. The venous patency score, thigh circumference, calf circumference, venous clinical severity score (VCSS), and chronicvenous insufficienc questionnaire-14item (CIVIQ-14) scores were recorded pre- and postsurgically, and the patency of stent was statistically evaluated by a comprehensive assessment of the postoperative 12-month angiography. ResultsOperative success was achieved in all the 64 patients. The aspiration time was 300－480 s [(313±32) s], and the operative time was 80－120 min [ (97±21.5) min]. No complications such as bleeding and hematoma occurred after operation. The hospitalization time was 5－12 d [ (7.5±2.8) d]. After operation, the patency score of vein and stent and the difference of thigh circumference diameter decreased or reduced, and the difference were statistically significant (P<0.001). The score of VCSS and CIVIQ-14 decreased or increased significantly after the operation, and the difference were statistically significant (P<0.05). Color Doppler ultrasound was performed at the first, third and sixth months after operation, and anterograde venography of lower limbs was performed at at the 12th month. Only one patient had thrombosis recurrence at one month after operation, and finally developed into post-thrombosis syndrome of deep veins of lower limbs after anticoagulant conservative treatment. The veins and stents of the rest patients were unobstructed. ConclusionAngioJet thrombectomy, together with iliac vein stenting, could effectively expedited clot removal, reduced limb swelling; prevented post-thrombotic syndrome recurrence and significantly improved quality of life for patients with acute lower extremity deep venous thrombosis.