Archibald Leman Cochrane（1909 to 1988）was a physician and clinical epidemiologist from the UK. The basic theroy of evidence-based medicine was established because of his influential book, Effectiveness and Efficiency: Random Reflections on Health Services published in 1972. The randomized controlled trial and systematic review promoted by Archie has become the key stone of evidence-based medicine. He was known as one of the forefathers of evidence-based medicine because of his outstanding contribution. In commemoration of Arichie Cochrane, The Cochrane Collaboration was named after him. His legendary life story and the early stages of the development of evidence-based medicine are introduced in this article.