ObjectiveTo investigate the clinical value of multi-slice spiral CT perfusion imaging for blood supply of pulmonary mixed ground-glass nodules (mGGN). MethodsThe mGGN patients were retrospectively analyzed from March 2011 to May 2015 in Affiliated Hospital of Hebei University of Engineering, Handan First Hospital and Xingtai People's Hospital. Multi-slice spiral CT perfusion imaging for blood supply was applied to evaluate the blood supply of solid lesions in mGGN, and the diagnostic values of CT perfusion parameters were compared for differentiating the benigh mGGN from the malignant mGGN. ResultsTotally 97 mGGN patients were enrolled in this study, in which 80 were malignant mGGN and 17 were benigh mGGN. Blood volume (BV), peak enhancement image (PEI) and permeability surface (PS) in malignant mGGN lesions were higher than those of benign lesions, while the time to peak was less than that of benign lesions, and the differences were all statistically significant (P < 0.05). BV, PEI and PS in minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) patients were significantly higher than those in the patients with precancerous lesions (P < 0.05). BV and PS in IAC patients were significantly higher than those in MIA patients (P < 0.05). Logistic regression analysis showed that IAC, MIA and the precancerous lesions, BV, PEI and PS were positively correlated with mGGN. Receiver operating characteristic (ROC) curve showed that the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy rates with BV+PS+PEI combined, were 95.28%, 86.65%, 91.10%, 87.52% and 91.76%, respectively, while the area under ROC curve was significantly higher than those with single parameter (P < 0.05). ConclusionMulti-slice spiral CT perfusion imaging can evaluate the blood supply of mGGN, and BV+PS+PEI combined can be used in differentiation of the benigh and malignant mGGN.