Objective To review the current situation of alginate-based biomedical materials, especially focus on the clinical strategies and research progress in the clinical applications and point out several key issues that should be concerned about. Methods Based on extensive investigation of domestic and foreign alginate-based biomedical materials research and related patent, literature, and medicine producted, the paper presented the comprehensive analysis of its research and development, application status, and then put forward several new research directions which should be focused on. Results Alginate-based biomedical materials have been widely used in clinical field with a number of patients, but mainly in the fields of wound dressings and dental impression. Heart failure treatment, embolization, tissue engineering, and stem cells culture are expected to become new directions of research and products development. Conclusion Development of alginate-based new products has good clinical feasibility and necessity, but a lot of applied basic researches should be carried out in the further investigations.
ObjectiveTo explore the influence of three central venous catheter biomedical materials (polyurethane, silicone, and polyvinyl chloride) on the proliferation, apoptosis, and cell cycle of Xuanwei Lung Cancer-05 (XWLC-05) cells so as to provide the basis for clinical choice of central venous catheter. MethodsXWLC-05 cells were cultured and subcultured, and the cells at passage 3 were cultured with polyurethane, silicone, and polyvinyl chloride (1.0 cm × 1.0 cm in size), and only cells served as a control. At 24, 48, and 72 hours after cultured, MTT assay was used to detect the cellular proliferation and flow cytometry to detect the cell cycle and apoptosis. At 72 hours after cultured, inverted microscope was used to observe the cell growth. ResultsInverted microscope showed the cells grew well in control group, polyurethane group, and silicone group. In polyvinyl chloride group, the cells decreased, necrosed, and dissolved; residual adherent cells had morphologic deformity and decreased transmittance. At 24 and 48 hours, no significant difference in proliferation, apoptosis, and cell cycle was found among 4 groups (P gt; 0.05). At 72 hours, the proliferations of XWLC-05 cells in three material groups were significantly inhibited when compared with control group (P lt; 0.05), and the cells in polyvinyl chloride group had more significant proliferation inhibition than polyurethane group and silicone group (P lt; 0.05), but there was no signifcant difference in proliferation inhibition between polyurethane group and silicone group (P gt; 0.05). Compared with the control group, three material groups had significant impact on the rate of apoptosis and cell cycle: polyvinyl chloride group was the most remarkable, followed by silicone group, polyurethane group was minimum (P lt; 0.05). ConclusionPolyvinyl chloride can significantly impact the proliferation, apoptosis, and cell cycle of XWLC-05 cells; polyurethane has better biocompatibility than polyvinyl chloride and silicone
Objective To summarize the developmental process of biomedical materials and regenerative medicine. Methods After reviewing and analyzing the literature concerned, we put forward the developmental direction of biomedical materials and regenerative medicine in the future. Results Biomedical materials developed from the first and second-generations to the third-generation in the 1990s. Regenerative medicine was able to help the injured tissues and organs to be regenerated by the use of the capability of healing themselves. This kind of medicine included the technologies of the stem cells and the cloning, the tissue engineering, the substitute tissues and organs, xenotransplantation and soon. Conclusion The third-generation biomaterials possess the following two properties: degradation and bioactivity; and they can help the body heal itself once implanted. Regenerative medicine is a rapidly advancing field that opens a new and exciting opportunity for completely revolutionary therapeutic modalities and technologies.
ObjectiveTo summarize the current research status of alginate derivatives based on biomedical materials, and analyze several key points as novel clinical products. MethodsThe general preparation and application methods of alginate derivatives based on biomedical materials at home and abroad were reviewed. The present status and problems were analyzed. ResultsThe derivation methods to prepare alginate derivatives include crosslink, sulfation, biological factors derivatization, hydrophobic modification, and graft copolymerization. With excellent bionic performance of structure and properties, many alginate derivatives are available for tissue engineering scaffolds, artificial organs, and drug delivery systems etc. However, more systematic applied basic research data should be collected and statistically analyzed for risk managements. ConclusionAlginate derivatives have good feasibility as novel medical products, meanwhile, systematic evaluation and verification should be executed for their safety, effectiveness, and suitability.
In order to fully implement the ethical principles of biomedical researches and to better safeguard the legitimate rights and interests of the subjects, this paper begins from the research design and closely combines with the ethical practice of biomedical research review, seriously analyzes the key implementation points of the ethical free and compensation principles in biomedical research, including intervention study, random allocation, follow-up research and new medical techniques and so on, also will provide the beneficial reference for comprehensive formulation of enforcement regulation of ethics principle of biomedical research in the future.
Biomedical metal materials have always been a major biomedical material with a large and wide range of clinical use due to their excellent properties such as high strength and toughness, fatigue resistance, easy forming, and corrosion resistance. They are also the preferred implant material for hard tissues (bones and teeth that need to withstand higher loads) and interventional stents. And nano-medical metal materials have better corrosion resistance and biocompatibility. This article focuses on the changes and improvements in the properties of several typical medical metal materials surfaces after nanocrystallization, and discusses the current problems and development prospects of nano-medical metal materials.
In 2016, the Sichuan University established the “West China National Key Laboratory Innovation Class” to explore a new model for cultivating outstanding undergraduate talents in the field of biomedicine. Through the formation of a multidisciplinary cross-faculty team, strengthening early-stage research practices, refining evaluation and incentive mechanisms, and enhancing professional identity, this class has nurtured biomedical talents with broad interdisciplinary perspectives, multidisciplinary intersections, and innovative thinking. This article summarizes the construction experience and achievements of the “West China National Key Laboratory Innovation Class”, aims at providing a reference for the cultivation of top-tier talents in the field of biomedical sciences in China and promoting the enhancement of the quality of top-tier talent cultivation in foundational disciplines in universities.
Methylcellulose is a semi-flexible cellulose ether derivative, whose hydrogels are thermosensitive and reversible, with good biocompatibility and adjustable function, and its application has attracted much attention in the biomedical field. In this paper, the application of methylcellulose-based thermo-sensitive hydrogels in biomedical field was reviewed. Based on the mechanism of gelation and influencing factors of methylcellulose, this paper focused on the recent advances in biomedical applications of methylcellulose-based hydrogels, including drug delivery, regenerative medicine, and other related fields. The current achievements in these fields were summarized in the form of lists in this paper to provide ideas and tendencies for future research. Finally, the future development of multifunctional methylcellulose-based hydrogel materials with improved performance was also discussed.