Objective To study the clinical effects of laparoscope combined with choledochoscope in patients with cholecystolithiasis and choledocholithiasis. Methods Clinical data of 74 patients with cholecystolithiasis and choledocholithiasis between Mar. 2009 and Feb. 2011 in our hospital were retrospectively analyzed. Among them， 37 cases underwent the laparoscope combined with choledochoscope operation （referred to as the double mirror operation group） and 37 cases underwent the conventional open operation （open operation group）. The intraoperative conditions， therapeutic effect， and complications of patients in 2 groups were compared. Results The stone clearance rates of the two groups were 100%. The recurrence rate of 2 groups in the follow-up process was no significantly difference （P＞0.05）. In the double mirror operation group， the operative time was significantly longer than that open operation group （P＜0.01）；the intraoperative bleeding was significantly less than that open operation group （P＜0.01）；the anal exhaust time after operation， get out of bed time after operation， and total duration of hospitalization were significantly shorter than that open operation group （P＜0.01）；and the incidence of postoperative complications was significantly lower than that open oper-ation group（P＜0.01）. Conclusion Laparoscope combined with choledochoscope in treatment of cholecystolithiasis and choledocholithiasis patients has exact effects， with minor trauma， quicker recovery， and fewer complications， and it’s worthy of promotion.