ObjectiveTo study the etiology, pathogenesis, clinical manifestations, diagnosis, treatment and prognosis of hemophagocytic syndrome (HPS). MethodsBetween February 2011 and October 2013, the causes, clinical manifestations, treatment and prognosis of 12 cases of HPS were retrospectively analyzed, and related literatures were reviewed. ResultsThere were 4 males and 8 females aged from 23 to 79 years old. Clinical features included fever (100.0%), lung infection (83.3%), enlarged lymph nodes (50.0%), bleeding (25.0%), splenomegaly (16.7%), and hepatomegaly (8.3%). Laboratory test results showed hemophagocytosis in bone marrow (100.0%), elevated ferritin (91.7%), thrombocytopenia (100.0%), decreased count in white blood cells (83.3%), decreased fibrinogen (66.7%), and hypertriglyceridemia (58.3%). Ten cases were related with infection, and 2 were related with diffused large B cell lymphoma. Nine patients died, 2 were cured, and one discharged himself from the hospital. ConclusionHPS is an uncommon disease, in which infection-associated HPS is the most common. The clinical presentation is complex, usually associated with multi-organ dysfunction, aggressive course, and high mortality rate.
ObjectiveTo analyze the related risk factors for catheter-associated urinary tract infection in the Intensive Care Unit (ICU), and make corresponding nursing countermeasures. MethodsBy target monitoring of catheter-associated urinary tract infection in 184 patients in the ICU from 2011 to 2012, infection risk factors were analyzed. The measures of nursing interventions had been taken since January 2012, and the effects before and after the intervention were contrasted and evaluated. ResultsBefore the intervention, 951 out of 1 229 patients in 2011 had indwelling catheter, and catheter-associated urinary tract infection occurred in 127 patients with an infection rate of 13.35%. After the intervention, 841 out of 1 437 in 2012 had indwelling catheter, and catheter-associated urinary tract infection occurred in 57 patients with an infection rate of 6.78%. ConclusionTaking effective intervention measures can effectively reduce the ICU catheter-associated urinary tract infection and it also ensures the safety of medical care.
ObjectiveTo explore the risk factors for and preventive measures of orthopedic perioperative surgical site infection. MethodsWe retrospectively analyzed the clinical data of 2 752 cases of orthopedic surgery performed from January 2010 to December 2012. The risk factors for such infection were analyzed and certain preventive measures were put forward. ResultsA total of 97 patients were infected with a surgical site infection rate of 3.52%. The surgical site infection was closely related to ages, basic diseases, surgical site, types of incision, preoperative hospital stay, operative time, urgent elective surgery, the use of antibiotics, medical staff hand hygiene and other factors, of which the rate of infection after amputation was the highest, reaching 23.81% (20/84). ConclusionMaking full preparations before operation, strengthening medical staff's hand disinfection, prophylactic antibiotics, good precautions and regulations in operation, and nursing meticulously after operation can be taken to prevent and reduce surgical site infection in orthopedic operation patients effectively.