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  • Clinical Significance of Combined Detection of Expressions of CK5/6 and Ki-67 in Breast Cancer

    Objective To detect the expressions of CK5/6 and Ki-67 in breast cancer, and explore the clinical significance. Methods The expressions of CK5/6 and Ki-67 were detected by immunohistochemistry in 162 cases of breast cancer . The correlation between CK5/6 expression and Ki-67 expression and the relationship of the expressions of two factors to the clinicopathologic factors were analyzed. Results There were 12 cases of the triple negative breast cancer 〔negative estrogen receptor (ER), negative progesterone receptor (PR), and negative Her-2〕 in 162 patients with breast cancer. The positive rates of CK5/6 and Ki-67 in the breast cancer tissues were 30.9% (50/162) and 65.4% (106/162),respectively. The positive rates of CK5/6 and Ki-67 in the patients with triple negative breast cancer were significantly higher than those of non-triple negative breast cancer 〔CK5/6:75.0% (9/12) versus 27.3% (41/150), χ2=11.837, P=0.001;Ki-67:100% (12/12) versus 62.7% (94/150), χ2=6.847, P=0.009〕. The expressions of CK5/6 and Ki-67 in the breast cancer tissues were not associated with age (P>0.05), but they were associated with histology grade (P<0.05). The expression of CK5/6 wasn’t associated with tumor size and lymph node status (P>0.05), but the expression of Ki-67 was associated with them (P<0.05). The expression of CK5/6 in the breast cancer tissue had a positive correlation with the expression of Ki-67 in the breast cancer tissue (rs=0.271, P=0.000). There were 64 cases when the expression of Ki-67 was (++) and (+++), the positive rate of CK5/6 was 43.8% (28/64) and it was significantly higher than that when the expression of Ki-67 was (-) and (+) 〔22.4% (22/98), χ2=8.233, P=0.004〕. The positive expressions of CK5/6 and Ki-67 in the breast cancer tissues were negatively correlated with the expressions of ER and PR (CK5/6 and ER:rs=-0.446, P=0.000;CK5/6 and PR:rs=-0.370, P=0.000;Ki-67 and ER:rs=-0.518, P=0.000;Ki-67 and PR:rs=-0.515, P=0.000). The positive expressions of CK5/6 and Ki-67 in the breast cancer tissue were not correlated with the Her-2 expression (CK5/6 and Her-2:rs=0.105, P=0.183;Ki-67 and Her-2:rs=0.068, P=0.393). Conclusion The expressions of CK5/6 and Ki67 not only can evaluate the basic rules of breast cancer from origin and development, but also they are beneficial to choose the chemotherapy of different patients.

    Release date:2016-09-08 10:23 Export PDF Favorites Scan
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