ObjectiveTo discuss the influence of ultracision versus electrotome on the immune function and stress reaction in patients after rectal cancer Miles operation. MethodA retrospective analysis was performed on 82 rectal cancer patients who received Miles operation between February 2007 and August 2012. Among them, 45 accepted ultracision, and 37 received electrotome operation. We compared the two groups in terms of abdominal and perineum surgery time, blood loss volume, drainage volume within 72 hours after operation, and analyzed the CD3+, CD4+, CD8+, CD4+/CD8+ ratio by flow cytometry before and after operation. In addition, we tested the white blood cell count, percentage of granulocyte, C-reaction protein (CRP), and interleukin (IL)-6 three days after operation. ResultsThere was no obvious difference in CD3+, CD4+, CD8+, CD4+/CD8+ ratio between the two groups. However, the incidence of blood loss volume, abdominal operation time, perineum operation time, drainage volume within 72 hours after operation, white blood cell count, percentage of granulocyte, CRP, IL-6 in the ultracision group was dramatically lower compared with the electrotome group (P<0.05). ConclusionsThere is no significant difference in the influence on the immune function between the two kinds of operation methods, but ultracision can achieve faster recovery and smaller stress reaction after operation. It is worthy of clinical popularization.