ObjectiveTo introduce the experience in diagnosing and treating cholecystoenteric fistula (CEF) during laparoscopic cholecystectomy (LC). MethodsFive cases with CEF in a series of 4 200 LC cases were reviewed.All of the five patients were proved to have CEF during operations.There were four cholecystoduodenal fistulas and one cholecystocolic fistula. One case with cholecystoduodenal fistula was treated by a suturing of the fistula under laparoscopy; 1 case was closed with titaniun and 2 cases were converted to laparotomy and fistulectomy.The patient with cholecystocolic fistula clips was treated by a suturing of the fistula under laparoscopy. ResultsAll the patients had got good recovery without complications.Conclusion CEF is a rare complication of cholelithiasis.If the diagnosis is made before operation, open operation might be a better choice.But if the diagnosis was made during the LC operation, suture closure or clip closure or stapler closure of CEF under laparoscope might be chosen for an experienced surgeon.