ObjectiveTo systematically review the diagnostic value of automatic breast volume scanner (ABVS) and handheld ultrasound (HHUS) for benign and malignant breast lesions.MethodsPubMed, EMbase, Web of Science, Biosis Preview, The Cochrane Library, WanFang Data, CNKI, VIP and SinoMed databases were electronically searched to collect studies on HHUS versus ABVS for benign and malignant breast lesions from inception to May 31st, 2019. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, and then, meta-analysis was performed by using Meta-Disc software.ResultsA total of 24 studies were included. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio for HHUS were 0.83 (95%CI 0.82 to 0.85), 0.81 (95%CI 0.79 to 0.82), 19.71 (95%CI 14.93 to 26.01), 4.05 (95%CI 3.49 to 4.69), 0.22 (95%CI 0.18 to 0.26), and for ABVS were 0.90 (95%CI 0.89 to 0.92), 0.88 (95%CI 0.87 to 0.89), 76.86(95%CI 55.13 to 107.17), 7.40 (95%CI 6.07 to 9.04), 0.11 (95%CI 0.09 to 0.14), respectively. The areas under the summary receiver operating characteristic curves in the differentiation of benign and malignant breast lesions were 0.88 and 0.96 for ABVS and HHUS, respectively.ConclusionThe current evidence shows that ABVS has higher value than HHUS in the diagnosis of benign and malignant breast tumor. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.