As the global health crisis erupts, there is an unprecedented focus on evidence across all sectors, becoming a critical trigger for changing research plans, development, synthesis, implementation, and evidence-informed decision-making. The establishment of the Global Commission on Evidence and the publication of two reports further emphasize the significance of evidence-informed decision-making in addressing social challenges. With the dissemination and development of evidence-based social science, there is a need to continually improve the ecosystem from evidence to decision and provide rigorous methods and approaches for different decision-makers to address social challenges. This article aims to interpret the Evidence Commission Report and explain the demand and supply of evidence, global public goods, and eight most-important Evidence Commission recommendations that can be used to address most social challenges. It also presents the key issues and insights that the evidence-based social science ecosystem faces from evidence to decision-making, putting evidence at the center of everyday work and life.