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find Author "FENG Xueguo." 1 results
  • Ischemic Postconditioning Protects Elderly Rat Hearts against Ischemia-reperfusion Injury via P-Akt Signaling Pathway

    Objective To explore the impact of ischemic postconditioning on ischemia-reperfusion injury in isolatedelderly rat hearts and their relation with P-Akt. Methods A total of 30 healthy elderly SD rats (21-23 months old, male or female) with their body weight of 450-500 g were divided into 3 groups: control group, ischemia-reperfusion group, and postconditioning group, with 10 rats in each group. Coronary artery blood flow,myocardial infarction size, phosphorylatedAkt (p-Akt) expression, and changes in myocardium and mitochondria were detected. Results Coronary artery blood flow of the postconditioning group was significantly higher than that of the ischemia-reperfusion group (6.4±1.2 ml/min vs.3.1±1.2 ml/min, P<0. 01), and myocardial infarction size of the postconditioning group was significantly smaller thanthat of the ischemia-reperfusion group (35.0%±2.0% vs. 55.7%±3.6%, Plt;0. 05). The expression of P-Akt was significantlyhigher, and myocardial fibers and mitochondria were preserved better in the postconditioning group than the ischemia-reperfusion group. Conclusion Ischemic postconditioning can protect isolated elderly rat hearts against ischemia-reperfusion injury, which may be related to P-Akt activation.

    Release date:2016-08-30 05:47 Export PDF Favorites Scan
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