ObjectiveTo review the researches of the role of the facet joint orientation (FJO) in degenerative spondylolisthesis (DS). MethodsRelated literature concerning the FJO in patients with DS was extensively reviewed and comprehensively analyzed in 4 terms of the basic concepts, measurement methods, the controversial etiology, and the clinical significance. ResultsThe multiplanar reformation of spiral CT is expected to become a new method of studying the FJO. The causal relationship between the sagittal FJO and DS is still controversial, but further prospective studies are needed to resolve this issue. The sagittal FJO is very important in the prevention of DS and the choice of surgery plan. ConclusionThe etiologic relationship between the FJO and DS need to be further studied.