In order to repair the intraoral defects after extensive resection of oral carcinoma with radical neck lymph nodes dissection, the nasolabial myocutaneous flap was prepared with its pedicle which only contained the facial artery and anterior facial vein. After removal of the tumor, the flap was used to cover the intraoral defect. Altogether 15 cases of oral squamous cell carcinoma were treated by this method. Seven out of 15 cases had their cervical lymph nodes involved. The tumor in all cases were located in one anatomical region, without involvement of accessory nerve or metastasis. All the flaps survived after the operation. There was no recurrence of tumor in any case after being followed up from 0.5-2 years. Removal of tumor and repaire of the defect by pedided naso-labial myocutaneous flap could be done in one stage. The detail of the process was introduced. Its feasibility and application were discussed. It was suggested that preserving the facial vessels be a kind of modified method of radical neck lymph nodes dissection, and the nasolabial myocutaneous flap have some clinical value in repair of the defect after radical operation of oral carcinoma.