【摘要】 目的 探讨早期微创腹腔置管灌洗在重症急性胰腺炎（severe acute pancreatitis，SAP）治疗中，对减轻炎性反应的作用。 方法 选择2007年1月-2009年6月收治的SAP患者56例，随机分为早期微创腹腔置管灌洗组（灌洗组，n=28）和常规治疗组（对照组，n=28）；两组同时给予生长抑素，抑酸，抗感染，保持水、电解质及酸碱平衡等综合治疗，灌洗组在常规治疗基础上早期予以微创腹腔置管灌洗。检测两组治疗前及治疗后2、5、7 d C反应蛋白（C-reactrve protein，CRP）、血清肿瘤坏死因子α（tumor necrosis factor α，TNF-α）、 白细胞介素6（interleukin，IL-6）、IL-8水平。 结果 两组治疗前CRP、TNF-α、IL-6、IL-8水平差异无统计学意义（Pgt;0.05），治疗后2、5、7 d比较差异有统计学意义（Plt;0.05）。 结论 早期微创腹腔置管灌洗操作简便易行、创伤小、疗效佳，对减轻SAP所致的全身炎性反应具有较好效果，是治疗SAP有效方法之一。【Abstract】 Objective To explore the effect of the early minimally invasive peritoneal lavage in severe acute pancreatitis (SAP) from Januany 2007 to June 2009. Methods A total of 56 cases of SAP were randomly divided into early minimally invasive peritoneal lavage group (lavage group, n=28) and conventional treatment group (control group, n=28). The patients were given comprehensive treatment, including somatostatin, acid suppression, anti-infection, and maintaining water, electrolyte, and acid alkali balance.In lavage group, the patients were treated with early minimally invasive peritoneal lavage in addition.The levels of C reactive protein(CRP), serum tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and interleukin 8(IL-8)were detected before and 2, 5, 7 days after tretment. Results There was no significant difference in CRP, TNF-α, IL-6, or IL-8 before treament between the two groups (Pgt;0.05). There were significant differences in CRP, TNF-α, IL-6, and IL-8 after treatment between the two groups (Plt;0.05). Conclusion Early minimally invasive peritoneal lavage is a simple, minially invasive, and effective techinique in treating SAP.