目的 探讨缝合治疗在膝关节内侧半月板桶柄状撕裂中的应用及效果。 方法 对2010年6月－2012年7月18例膝关节内侧半月板桶柄状撕裂患者，采用多种缝合材料、缝合方式相结合的方法予以救治。 结果 18例患者术后即时MRI均显示内侧半月板位置、形态恢复良好。随访12～26个月，所有患者膝关节活动度均正常，Lysholm评分术前（45.0 ± 3.5）分，术后末次随访（93.0 ± 5.1）分，差异有统计学意义（t=2.064，P＜0.05）；国际膝关节文献委员会膝关节评估表评分，术前（49.0 ± 1.5）分，术后（92.0 ± 3.6）分，差异有统计学意义（t=2.205，P＜0.05）；无膝关节疼痛，麦氏试验阴性，术后MRI显示内侧半月板愈合良好。 结论 采用缝合方法可挽救内侧半月板桶柄状撕裂，恢复半月板稳定性及正常功能。
Objective To observe the growth of orthotopic transplanted tumor in nude mice after stomatin-like protein 2 (SLP-2) expression decreased, and to further study the role of SLP-2 in the development and progression of esophageal squamous cell carcinoma. Methods Using RNA interference technique, esophageal squamous cell carcinoma cell lines with specific expression of SLP-2 and stable expression of luciferase were established. The healthy female nude mice with weight ranging from 19 to 22 g were randomly divided into 3 groups (n=12), 6 mice were used to establish subcutaneous xenografts, and the other 6 mice were used to establish the orthotopic transplanted tumor model (Group 1: cell infected with SLP-2-1 plasmid; group 2: cell infected with SLP-2-2 plasmid; group 3: cell infected with SHGFP plasmid). Index of the experiment end was weight loss and poor general situation in any mouse. Before the nude mice were sacrificed, the luciferase value of the tumor was detected by using in vivo imaging technique. After the nude mice were sacrificed, the primary tumor was removed for pathology examination. Results There was no significant difference in region of interest (ROI) value between the group 1 and group 2 (P=0.943). The ROI value for both groups 1 and 2 was significantly lower than that in the group 3 (P=0.002, P=0.000). The primary tumor infiltrated into the muscularis propria of esophageal was observed in all groups. Conclusion SLP-2 is involved in the development and progression of esophageal squamous cell carcinoma, and the decrease of SLP-2 expression can inhibit the growth of esophageal squamous cell carcinoma.