Objectives To systematically review the economic burden of surgical treatment for ankle fracture in China. Methods PubMed, EMbase, CNKI, WanFang Data and VIP databases were electronically searched to collect studies on economic burden of surgical treatment for ankle fracture in China from inception to December 1st, 2017. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Description analysis were then performed by Excel software. Results A total of 67 studies were included. The analysis showed that: the average cost of hospitalization generally tend to rise during 2004 to 2013. The highest was 17 700 yuan in 2013. After 2013, the expense gradually stabilized. The average annual growth rate of hospitalization costs was 12.3% during 2004 to 2016. The percentage of hospitalization costs accounted for the per capita disposable income of households in region was stable during 2004 to 2016 (around 60%). Conclusions Although the average hospitalization costs in China generally show an upward trend, the percentage of hospitalization costs accounted for the per capita disposable income of household is relatively stable. The study on the indirect economic burden is required to be further carried out. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.