Ventricular assist device can provide the heart with a nonload circumstance and improve hemodynamics and energy metabolism of ischemic myocardium.With ventricular assistance,not only multiple organ failure is improved but also cardiac function and myocardial injury are resumed. In recent years, studies found that ventricular assistance have an impact on the myocardial interstitium on its structural protein-typeⅠ,Ⅲcollagens and their metabolism conditioning systems.It reverse adverse myocardial remodeling and improve cardiac function by changing myocardial collagen content and distribution.