目的:探讨预防性应用抗生素对肝硬化并发消化道出血预后的影响。方法:采用回顾性调查的研究方法,对肝硬化并发消化道出血共245 例应用抗生素情况及发生再次出血的关系进行分析。结果:预防性应用抗生素组82例1年内再出血23 例,占28.0 %;未用组163例1年内再出血77例,占47.2%,两组比较1年内再次出血率差异有统计学意义( Plt; 0.05) 。结论:预防性应用抗生素可以减少肝硬化并消化道出血患者一年内再次出血率。
ObjectiveTo investigate the diagnostic value of MRI hip joint unilateral oblique coronary scanning in the diagnosis of femoroacetabular impingement (FAI).MethodsFrom February to October 2014, 75 patients with hip joint pain who were highly suspected of FAI after X-ray or CT examination were selected as subjects. Using Siemens 1.5 T MR, fat-suppressed T2-weighted imaging sequences, T1-weighted imaging sequences, and proton density-weighted imaging sequences were used. For each patient two scan methods were used. Method A: on the sagittal image of the hip joint, the line of sight was parallel to the oblique coronal plane scan of the (one-sided) long axis of the femoral neck. Method B: on the cross-sectional image of the hip joint, the positioning line was parallel to the conventional hip joint coronal scan of the left and right femoral heads. McNemar test was used to compare the detection rates of FAI of the two methods.ResultThe detection rate of FAI of A-scanning [62.6% (47/75)] was higher than that of B-scanning [30.6% (23/75)], and the difference was statistically significant (P<0.001).ConclusionAn image obtained from a diagonal coronal scan parallel to the long axis of the femoral neck can more fully display the pathological changes of the acetabular labrum and the anatomy of the femoral head and neck joints, and the damage of the femoral head and neck junction, which provides a more reliable imaging basis for the clinician to diagnose FAI.
Objective To compare the systematic and lung pharmacokinetic parameters of moxifloxacin hydrochloride and explore a feasible tool to monitor drug concentration and evaluate therapeutic efficacy of respiratory fluoroquinolones. Methods Ten adult patients with community-acquired pneumonia or acute exacerbation of chronic bronchitis were enrolled.The subjects received a single dose of oral moxifloxacin hydrochloride 400 mg. Serum specimens were sampled at 0，1，2，3，4，8，24 h and sputum specimens were collected 0，1，2，4，8，20，24 h after administration，respectively.The serum and sputum concentrations of moxifloxacin hydrochloride were assayed by means of high-performance liquid chromatography. Standard pharmacokinetic parameters including peak concentrations(Cmax) and area under the concentration-time curve (AUC0-24 h) were assessed. Results Serum C(max) was（5.95±1.35）mg/L at 2 hours and serum AUC0-24 h was (58.72±8.11）mg·h-1·L-1 while sputum Cmax and AUC0-24 h were （16.18±6.47）mg/L at 3 hours and （138.04±78.29）mg·h-1·L-1 respectively，which were significantly higher than those in serum. Conclusion Oral administration of moxifloxacin hydrochloride to patients with respiratory infections results in rapid penetration into lung and maintain a one-fold drug concentration compared to blood concentration within 24 hours.Sputum drug concentration analysis demonstrates a superior pharmacokinetic profile of moxifloxacin in respiratory tract.
Objective To compare the effectiveness of the traditional center of tibial plateau as the entry point and digital technology in the design of intramedullary tibial nail point positioning method in total knee arthroplasty (TKA). Methods Between October 2011 and October 2012, 60 cases undergoing unilateral TKA and meeting the selection criteria were randomly divided into 2 groups: in group A (30 cases), the tibial plateau center as the entry point of tibial intramedullary positioning was used; in group B (30 cases), Mimics 10.01 software to simulate the guide rod point of tibial intramedullary positioning was used. There was no significant difference in gender, age, etiology, disease duration, sides, and preoperative knee range of motion, Hospital for Special Surgery (HSS) score, and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) between 2 groups (P gt; 0.05). Postoperative X-ray films were taken to measure the tibiofemoral angle and tibial angle; knee range of motion, and HSS and WOMAC scores were used to assess the activity of knee. Results The entry point of group B was located in front of the center of tibial plateau, which was inconsistent with the traditional entry point. The incision healed by first intention in all patients of 2 groups. The patients were followed up 6 to 12 months (mean, 8.6 months). The X-ray measurement at 1 week after operation showed no significant difference in tibiofemoral angle between 2 groups (t= — 6.65, P=0.72), but the anteroposterior and lateral tibial angles of group A were significantly lower than those of group B (P lt; 0.05). The knee range of motion, HSS score, and WOMAC score of 2 groups were significantly higher at 3 and 6 months after operation when compared with preoperative values (P lt; 0.05), and the values at 6 months were significantly increased than those at 3 months after operation (P lt; 0.05). HSS score and WOMAC score had no significant difference between 2 groups at 3 months after operation (P gt; 0.05), but the scores of group B were significantly higher than those of group A at 6 months (P lt; 0.05). The knee range of motion of group B was significantly better than that of group A at 3 months after operation (t=2.13, P=0.04), but no significant difference was found between 2 groups at 6 months (t=0.58, P=0.56). Conclusion Compared with the traditional intramedullary guide rod insertion point positioning, digital individualized design of entry point positioning has the advantages of more accurate lower limb force line, better recovery of knee function, and earlier 90°activities, but the long-term effectiveness needs further observation.
目的 探讨数字X线摄影（DR）的全景拼接技术在骨关节系统疾病中的临床应用价值。 方法 回顾分析2011年1月－2013年3月采用“连续多次曝光后手动软件拼接技术”及“狭缝连续拍摄自动软件拼接技术”所得的各100例（全脊柱50例，下肢全长50例）全景拼接图像，对图像质量进行评价，分析其技术特点及应用优势。 结果 两种拼接技术所得的全景拼接图像都清晰、连续、完整、质量合格，能有效满足临床诊疗需求，在质量上两者无明显差异。前者所需时间稍长，对操作者技术及经验要求较高，后者操作更显快捷方便，但设备较昂贵。 结论 DR全景拼接技术在骨关节系统疾病中有很好的普及推广应用价值，能为骨科临床提供新的更有价值的信息。
Thermoacoustic imaging (TAI) is a new non-invasive, non-ionization and nondestructive modality capable of high microwave contrast and high ultrasound resolution, and it has attracted extensive attention in recent years. This review introduces the technical principle, imaging system and imaging characteristics of TAI, and then introduces the application of TAI for breast cancer detection as an example. This review introduces the advantages of TAI in solving corresponding clinical problems in view of its high resolution and high contrast. In addition, it also explains the roles of TAI in medical diagnosis and treatment. Finally, the potential applications of TAI in medical diagnosis is introduced from many aspects and multiple perspectives. The future development of TAI in the challenges of current medical diagnosis is also prospected.