Objective To explore the value of multidetector row helical CT (MDCT) in the diagnosis of lymph node metastasis in adenocarcinoma of esophaogastric junction (AEG), and to study the pattern of lymph node metastasis of it. Methods The MDCT images of 60 patients with AEG who underwent operation in our hospital from Jan. 2011to Oct. 2012 were collected, in order to explore the value of MDCT in the diagnosis of lymph node metastasis in AEG, and to study the pattern of lymph node metastasis of it. Results With diameter upper 8 mm and the difference of the mean value of enhanced degree upper 70 Hu as the standard of lymph node metastasis, the Kappa value (0.819 and 0.718),sensitivity (83.1% and 91.8%), and specificity (78.9% and 83.5%) were all optimal. The lymph node metastasis rate was significantly higher in serosa invasion group than those of non-invasion group (P<0.05). The metastatic area of lymphnodes mainly concentrated around cardia (No. 7, 8, and 9 group), lesser curvature of the stomach, celiac axis, and hepato-gastric ligament (No. 10, 11, 12, and 14 group) with the metastasis rate of 83.8% and 82.3%, respectively. Conclusion MDCT is useful to confirm the features, location, and rules of lymph node metastasis in patients with AEG, which is helpful in accurately cleaning the lymph nodes.