目的 观察藏医滋补方“巴桑母酥油丸”对放射线-化学复合损伤小鼠骨髓不同细胞群增殖能力的影响，探讨其促进放射线-化学复合损伤机体外周血象恢复的机制。 方法 采用造血祖细胞集落分析方法、流式细胞术，检测灌胃巴桑母酥油丸后放射线-化学复合损伤小鼠骨髓细胞中早期红系祖细胞（CFU-E）、晚期造血祖细胞（BFU-E）、粒-巨噬系祖细胞（CFU-GM）、巨核系祖细胞（CFU-Meg）集落产率、骨髓细胞增殖周期各时相细胞比例、造血干细胞抗原-1（Sca-1）免疫表型阳性细胞数变化情况。 结果 巴桑母酥油丸组骨髓细胞S+G2/M期细胞比例高于生理盐水组（P＜0.05）和自然恢复的空白组（P＜0.01）；CFU-E、BFU-E、CFU-GM集落产率高于生理盐水组和空白组（P＜0.05）；CFU-Meg集落产率、Sca-1+细胞数在各组间差异无统计学意义（P＞0.05）。 结论 巴桑母酥油丸对放射线-化学复合损伤小鼠骨髓细胞具有促进增殖的作用，这可能是其促进放射线-化学复合损伤机体外周血象恢复的途径，但对不同阶段、不同系别的造血细胞其促进作用不同。
Adenosine activated protein kinase (AMPK) is a serine/threonine protein kinase that can sense the change of intracellular energy. AMPK plays a critical part in the occurrence and development of tumors. According to the difference of AMPK catalytic subunits, it is divided into AMPKα1 and AMPKα2. The AMPKα1 subunit is the catalytic subunit of AMPK and is extensively distributed in the various tissues and organs. This review focuses on the structural, activated and functional aspects of AMPKα1 and the involvement of AMPKα1 in the regulation of intracellular substance metabolism, and summarizes the respective performances of AMPKα1 in different cancers and the corresponding potential applications of AMPKα1 as a drug target in the relevant cancers. AMPKα1 can be used as a diagnostic marker or drug target for cancer diagnosis and therapy, providing an idea for cancer treatment, which has importance clinical significance.