ObjectiveTo explore family care and its influence on the life quality of schizophrenia patients. MethodsBetween September 2011 and March 2012, 101 schizophrenia patients were investigated with Questionnaire of Family Care and Quality of Life Inventory and were divided into two groups in order to compare their life quality. According to the scores of Questionnaire of Family Care, 56 subjects were in support group and 45 subjects were in control group. ResultsAmong the 101 patients, 55.45% had good family care and 44.55% had not. In the support group, there was no significant correlation between family care and life quality in the first month and the third month (r=0.023, P=0.894; r=-0.072, P=0.587), while there was a significant correlation between family care and life quality in the sixth month (r=-0.322, P=0.032). In the control group, there was no significant differences in the score of family care and life quality in the first, third and sixth month (r=0.021, P=0.893; r=0.114, P=0.482; r=1.863, P=0.226). ConclusionLong-term family care is significantly correlated with the life quality of schizophrenia patients. If schizophrenic patients get more poor family care, they will have lower life quality. It's important to create a good and comfortable environment for the patients.
ObjectiveTo investigate the effects of specific farnesiod X receptor(FXR) agonist on growth of colon cancer cells in vitro. MethodsThe effects of specific FXR agonist(GW4064) on the growth of HCT116 cells of colon cancer were studied in vitro by using MTT and flow cytometry. The mRNA expressions of FXR and vascular endothelial grouth factor(VEGF), were determined by using RT-PCR. ResultsThe FXR specific agonist GW4064 could increase the FXR mRNA expression of HCT-116 cells of colon cancer, downregulation of VEGF mRNA expression, and had obvious inhibitory effect on growth of HCT-116 cells, and promoted the apoptosis of HCT116 cells in a dose and time dependence. ConclusionsGW4064 can significantly inhibit colon cancer cells in vitro. FXR may be a potential treatment arget of colon cancer.