ObjectiveTo investigate the influence of uncovertebral joint foraminal part excision on the motion response, stability and clinical outcomes after single-level cervical disc replacement. MethodsThe clinical data of 57 patients with cervical spondylotic radiculopathy, who underwent single-level Prestige LP cervical disc replacement in West China Hospital of Sichuan University from January 2012 to January 2015, were retrospectively analyzed.According to whether to have the uncovertebral joint foraminal part excision in the process of operation, two groups were divided, named excision group and non-excision group.The Japanese Orthopedic Association score (JOA), neck disability index (NDI) and visual analogue score (VAS) were used to evaluate the clinical outcomes pre-and post-operatively.The stability, overall cervical alignment, range of motion of treated levels in flexion-extension and lateral bending, and the transverse and longitudinal diameter of intervertebral foramen were measured by X-ray and CT-3D examination.The complications and reoperations were also recorded. ResultsThere were statistically significant improvement in the JOA, NDI, neck VAS and arm VAS scores in both of the two groups after the surgery (P < 0.05).The improvement of the NDI and the arm VAS scores were more obvious after the surgery in excision group.The overall cervical alignment, the range of motion of treated levels in flexion-extension and lateral bending were well maintained post-operatively (P > 0.05), and the differences between the two groups were not significant (P > 0.05).The transverse diameter of intervertebral foramen was significantly increased in excision group post-operatively (P < 0.05) while the longitudinal diameter was not (P > 0.05);both of the transverse and longitudinal diameter of intervertebral foramen didn't differ much post-operatively in the non-excision group (P > 0.05).All the prostheses showed a good stability.No prostheses shift, dislocation or unfixed prostheses were found. ConclusionUncovertebral joint foraminal part excision can be used in single-level Prestige LP cervical disc replacement, which is safe and reliable.