ObjectiveTo investigate the effect of early different nutritional diet on the expression of IGFs and its receptor in retarded intrauterine growth rat pups. MethodsThe IUGR rat model was established by food restriction of pregnant rats.Newborn IUGR rats were randomly divided into four groups:IUGR model (S/N) group,IUGR high sugar diet (A) group,IUGR high protein diet (B) group,IUGR high fat (C) group.Only the mother rats were given those different diets individually,and all IUGR newborn pups were lactated for three weeks.All IUGR pups were fed with those different diets individually till the end of the month.Normal birth weight newborn rats were used as the control group fed with normal diet.Liver and lung tissues were detected by immunohistochemical staining and pancreatic tissues were stained with HE detection for all groups of rats. ResultsPolypeptide glycoprotein metalloprotease 12(ADAM12) test results each month showed no statistical difference (P>0.05).The determination results of plasma protein A (PAPP-A) in rat pups was statistically different among the groups in the first month (P<0.05),but no statistical difference was found in the second month,third month,and fourth month (P>0.05).TLR-4 test results had no statistical difference (P>0.05).Rat pancreatic tissue test results were statistically different in the first month (P<0.05),but the difference was not significant in the second month,third month,and fourth month (P>0.05). ConclusionADAM-12 and pregnancy associated PAPP-A expression results suggest that ADAM12 and PAPP-A may be closely related with rat catch-up growth,while the TLR-4 test results are not statistically different,but the chances of high glucose group and high fat group pancreatic inflammation are relatively large.