ObjectiveTo investigate the therapeutic effect of endovascular therapy for TASC-ⅡC/D lesion of iliac artery occlusion. MethodThe clinical data of 25 patients (28 limbs) who underwent endovascular therapy for TASC-ⅡC/D lesions of iliac artery occlusion were reviewed retrospectively. ResultsTwo limbs failed to recanalize the occlusions, recanalization rate was 92.86%. Twenty-six iliac arteries were successfully treated by percutaneous transluminal angioplasty and implanted stent. The ankle-brachial index increased from preoperative 0.23±0.18 to postoperative 0.76 ±0.19 (P < 0.05). Two patients had hematomas in puncture point, which were improved by conservative treatment. One patient had thrombosis in stent, which was disappeared by local thromblysis after thrombolytic catheter placement. Twenty patients (24 iliac arteries) were followed up for a mean time of 8 months (3-24 months). The follow-up rate was 85.71%. The limb patency rates of 6 months, 1-and 2-year was 85%, 80% and 73%, respectively. ConclusionEndovascular therapy for TASC-ⅡC/D lesion of iliac artery occlusion is safe and has a good short-term therapeutic effect, microtrauma and little complications.