Objective To investigate the relation between gaseous signal molecule hydrogen sulfide (H2S) and diseases. Methods Literatures about the advancement of H2S were reviewed and analyzed. Results H2S is recognized as a novel gaseous signal molecule. By acting specially on ＫATPchannels, H2S can relax smooth muscle cells to regulate blood pressure.It even plays an important roles in pulmonary hypertension, ischemia/reperfusion injury, neurotransmission， apoptosis and inflammatory reaction. Conclusion H2S has been regarded as the third gaseous signal molecule， which exerts many physiological and pathological effects on mammals, and will pave way for development of new drugs and provide therapeutic intervention for various diseases.
Objective To determine the effectiveness of sodium hyaluronate (SHA) in preventing intraperitoneal (IP) adhesion. Methods Thirty-eight rats were randomly divided into A,B,C groups, normal saline, 6% Dextran-40 or SHA were applied on the present serosal injury respectively, during operation. Biopsy was taken on the 14th postoperative day.Results There were statistically significant differences in the extent of adhesion among three groups (Ｐ＜0.01). Mild inflammatory changes and less fibrous proliferation were found in group C by microscopy and decreased production of collagen (by fibroblast) and active mesothelial cells proliferation were observed in group C under electron microscope. Conclusion SHA appeares to reduce the extent of postoperative IP adhesion, which is more satisfactory than Dextran-40.
【Abstract】Objective To investigate the influent factors on normal intraabdominal pressure （IAP） and establish the IAP regressive equation. Methods The IAPs of 106 hospitalized patients were determined through monitoring the bladder pressures. The relationship between IAP and 14 factors including age, gender, height, weight, body mass index （BMI）, previous and recent abdominal surgical history, reasons for admission，complications and their quantities were analyzed，respectively.Results The mean IAP of the hospitalized patients was 5.5 mm Hg with a range from 0.4 mm Hg to 12.8 mm Hg. The difference among IAPs of different grades of BMIs had statistical significance （F=5.550，P＜0.01）. The male IAPs were 2.0 mm Hg higher than the female IAPs，which had statistical significance （t=3.122，P＜0.01）. The other 12 factors had no significant effects on IAP （Pgt;0.05）. Conclusion Normal IAP is possibly influenced by gender and BMI，and it is individually different.
Objective To summarize the clinical significance of endoscopic treatment for obstructive jaundice. Methods The recently published literatures in domestic and abroad about endoscopic treatment for obstructive jaundice were reviewed. Results The results of endoscopic treatment for bile duct stones and bile duct surgery for biliary stricture had the same outcome. The endoscopic treatment could identify bile duct and duodenal periampullary tumors and lesions. Conclusion Endoscopic treatment for obstructive jaundice is a safe and effective method.