As the “power center” of the cell and the center of metabolic signaling, mitochondria play an important role before, during, and after cerebral ischemia. After ischemic stroke, molecules such as mitoNEET, optic atrophy 1, and mitochondrial division inhibitor 1 can play a neuroprotective role by regulating the state of the mitochondria. Mitochondria are not only energy-supplying organelles, but their biogenesis and movement also play an important role in neuronal growth, differentiation, synapse formation and neural circuit formation after ischemic stroke. Rehabilitation at all stages can play a therapeutic role by modulating mitochondrial function.