目的 对比A型超声角膜测厚仪、OrbscanⅡ眼前节分析仪和Pentacam眼前节分析仪测量准分子激光原位角膜磨镶术（LASIK）前后中央角膜厚度的差异。 方法 2010年10月－2011年3月，分别使用A型超声角膜测厚仪、OrbscanⅡ和Pentacam眼前节分析仪测量137例（274只眼）近视患者LASIK前后中央角膜厚度，并对测量结果进行配对t检验和Pearson相关性分析。 结果 LASIK术前A型超声、OrbscanⅡ和Pentacam测量值分别为（526.6 ± 34.1）、（516.6 ± 34.2）、（539.8 ± 31.5） μm，Pentacam测量值较A型超声和OrbscanⅡ测量值高，差异有统计学意义（P＜0.05），而A型超声和OrbscanⅡ测量值之间差异无统计学意义（P＞0.05）；LASIK术后6个月A型超声、OrbscanⅡ和Pentacam测量值分别为（448.2 ± 48.5）、（391.9 ± 58.5）、（451.5 ± 46.4） μm，LASIK术后A型超声和Pentacam测量值无差异（P＞0.05），而OrbscanⅡ测量值较A型超声和Pentacam低；Pearson相关分析显示，LASIK术后Pentacam和A型超声CCT测量值呈高度相关（P＜0.05）。 结论 3种仪器的中央角膜厚度测量值不可互换，LASIK术后A型超声和Pentacam量值较为准确。Objective To compare the difference in measurements of central corneal thickness (CCT) using A-scan, OrbscanⅡand Pentacam before and after laser in situ keratomileusis (LASIK). Methods Between October 2010 and March 2011, the CCT of 137 patients (274 eyes) were measured by A-scan, OrbscanⅡ and Pentacam, and the results were analyzed by paired t-tests and Pearson correlation. Results Before LASIK, the values of CCT measured by A-scan, OrbscanⅡ and Pentacam were (526.6 ± 34.1), (516.6 ± 34.2), and (539.8 ± 31.5) μm respectively; paired t-tests showed the CCT values obtained with Pentacam were significantly higher than those with other methods (P＜0.05), but there were no statistical significant differences between OrbscanⅡand Pentacam measurements (P＞0.05). Six months after LASIK, the values of CCT measured by A-scan, OrbscanⅡand Pentacam was (448.2 ± 48.5), (391.9 ± 58.5), and (451.5 ± 46.4) μm respectively; the CCT values obtained with A-scan and Pentacam didn’t differ much from each other (P＞0.05), and the CCT values obtained with OrbscanⅡwere lower than those obtained with A-scan and Pentacam. There was a high correlation between A-scan and Pentacam measurements. Conclusion The these methods measuring CCT could not be used interchangeably, and A-scan and Pentacam after LASIK were more precise than OrbscanⅡ.