【摘要】 目的 探讨老年糖尿病患者血清胱抑素C与血脂及高敏C反应蛋白的关系。 方法 2008年5月-2009年10月糖尿病患者共141例，其中糖尿病合并症组68例，单纯糖尿病组73例；另选取对照组51例。对入选者的血清胱抑素C、血脂及高敏C反应蛋白进行分析。 结果 老年男女糖尿病合并症组血清胱抑素C、高敏C反应蛋白、总胆固醇、甘油三酯及低密度脂蛋白胆固醇最高、高密度脂蛋白胆固醇最低，与对照组比较有统计学意义（Plt;0.05）、与单纯糖尿病组比较，无统计学意义（Pgt;0.05）。老年男女单纯糖尿病组高敏C反应蛋白、总胆固醇、甘油三酯高于对照组，组间比较，有统计学意义（Plt;0.05）。老年男女单纯糖尿病组血清胱抑素C与对照组比较，无统率学意义（Pgt;0.05）。老年女性单纯糖尿病组低密度脂蛋白胆固醇与对照组比较，有统计学意义（Plt;0.05）。老年男性糖尿病二组与对照组血清胱抑素C低于老年女性糖尿病二组与对照组，组间比较，无统计学意义（Pgt;0.05）。老年男性糖尿病患者血清胱抑素C与高敏C反应蛋白及血脂不相关。老年女性糖尿病合并症组血清胱抑素C与空腹血糖正相关；单纯糖尿病组血清胱抑素C与高密度脂蛋白胆固醇负相关、与低密度脂蛋白胆固醇正相关、与高敏C反应蛋白不相关。 结论 老年糖尿病患者高脂、高糖及低度炎症状态下，血清胱抑素C水平较高。血脂对血清胱抑素C的影响可能存在性别差异。随着动脉粥样硬化的加重，血清胱抑素C有升高趋势。【Abstract】 Objective To investigate the relationship between serum cystatin C concentration and lipid, hs-C reactive protein in the elderly with diabetes. Methods A total of 192 senile people form May 2008 to October 2009 were investigated. There were 141 patients with diabetes, in whom 68 were with cardiovascular and cor, cerebrovascular diseases, 73 were with diabetes only.There were 51 control subjects. The data of serum cystatin C, hs-CRP, TC, TG, HDL-C and LDL-C were analyzed. Results Serum cystatin C of elderly men was lower than that in elderly women, but no signifcant correlation between them was found (Pgt;0.05). Serum cystatin C, hs-CRP, TC, TG and LDL-C was higher, and HDL-C was lower in male and female diabetes subjects with cardiovascular and cor, cerebrovascullar diseases, than that in control subjects (Plt;0.05). Serum hs-CRP, TC and TG were higher in the elderly with diabetes only, than that in control subjects (Plt;0.05). LDL-C was higher in senile women with diabetes only, than that in female control subjects (Plt;0.05). Serum cystatin C with LDL-C in elderly women with diabetes only, with FPG in female diabetes subjects with cardiovascular and cor, cerebrovascular diseases had position correlation (Plt;0.05). No correlation were observed between serum cystatin C and hs-CRP in male and female diabetes subjects, and lipid in male diabetes subjects. Conclusions We speculate that high serum lipid, high glucose and low level of inflammation may result in increasing of serum cystatin C in senily people with diabetes. The influence of serum lipid on serum cystatin C may be different in male and female senile people.Along with atherosclerotic aggravating, the level of serum cystatin C was increasing.
目的 观察与分析体重异常老年男性血清前列腺特异性抗原（T-PSA）与生长激素（GH）水平及影响因素。 方法 以2009年1月－2012年6月，血清GH＜5 ng/mL、血清T-PSA＜4.5 ng/mL的老年男性共296例作为观察对象，依据体质量指数分为低体重组、正常体重组、超重组及肥胖组。依据年龄分为60～64、65～69、70～74及≥75岁四组。测定296例入选对象的血清T-PSA及GH并进行分析。 结果 随着年龄增长，血清T-PSA、GH渐增高。≥75岁年龄组血清T-PSA高于其他三组，差异无统计学意义（P＞0.05）。≥75岁年龄组血清GH高于其他三组，差异有统计学意义（P＜0.01）。超重组及肥胖组血清T-PSA低于正常体重组，差异有统计学意义（P＜0.01）。低体重组血清T-PSA稍低于正常体重组，差异无统计学意义（P＞0.05）。肥胖组血清GH低于超重及正常体重组，差异无统计学意义（P＞0.05）。低体重组血清GH低于正常体重组，差异无统计学意义（P＞0.05）。单因素相关分析显示血清T-PSA与年龄、GH正相关；与BMI负相关；与收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）及血脂不相关。血清GH与年龄、T-PSA、SBP、DBP正相关；与BMI、FPG及血脂不相关。校正年龄、BMI后，血清T-PSA与GH仍呈正相关。 结论 随着年龄增长，老年男性血清T-PSA、GH渐增高。老年男性非肢端肥大症者血清T-PSA与血清GH水平及BMI有关联，血清GH水平较高者，血清T-PSA也较高；血清T-PSA与BMI负相关。
目的:探讨老年代谢综合征者血清尿酸与血压、甘油三脂的关系。方法:163例入选者,MS组96例,对照组67例,对二组的SUA、BMI、WC 、SBP、DBP及TG进行分析。结果:MS组SUA较对照组高。MS组男性SUA与BMI正相关、女性与WC正相关;男女性MS组及对照组SUA与SBP及TG不相关。对照组女性SUA与DBP正相关。结论:SUA对老年女性DBP的维持可能有一定作用。TG对老年人SUA的影响有限;体重及脂肪聚集部位对SUA的影响,存在性别差异。