【摘要】 目的 观察自制富血小板血浆治疗难治性创口的临床疗效。 方法 2007年4月-2009年11月对38例难治性创口患者进行自制富血小板血浆治疗，观察创面愈合变化情况。 结果 38例患者中30例愈合，2例显效，2例有效，总有效率为90%。 结论 自制富血小板血浆治疗难治性创口是一种简便、安全、价廉、有效的治疗方式，特别适合中小（25~60 cm2）创面的难治性创口。【Abstract】 Objective To observe the clinical effect of homemade platelet-rich plasma on refractory wound. Methods Thirty-eight patients with refractory wound from April 2007 to November 2009 were treated by homemade platelet-rich plasma, and the changes in wound healing were observed. Results Thirty patients were healed, two patients were markedly effective, two patients were effective and the total effective rate was 90%. Conclusion Homemade platelet-rich plasma is a simple, safe, inexpensive and effective treatment on refractory wound, especially for small and medium refractory wounds (25-60 cm2).