ObjectiveTo explore the research hotspots of thyroid cancer nursing, and provide reference and guidance for future research on thyroid cancer nursing. MethodRelevant literature on thyroid cancer care was retrieved through the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) Core Database, and then analyzed the data using CiteSpace 6.2R4 software. ResultsThis study included a total of 1 096 Chinese literature and 263 English literature. The total number of publications was on the rise. The top 10 keywords in CNKI were: surgery, anxiety and depression, perioperative care, quality of life, complications, postoperative care, clinical pathway, rapid recovery surgery, differentiated thyroid cancer, and psychological care. Except for “rapid recovery surgery”, the mediating centrality of other key words was greater than 0.1. The top 10 keywords in WOS were: quality of life, management, 131I, papillary thyroid cancer, surgery, impact, anxiety, prevalence, risk factor, and differentiated thyroid cancer. Among them, “quality of life” played an important intermediary role in co-occurrence networks, with the highest centrality of 0.34. ConclusionsQuality of life, mental health, perioperative period, and microcarcinoma are research hotspots in thyroid cancer care both domestically and internationally. The management of patient quality of life and symptom management is the development trend of future research. Further research on thyroid cancer care needs to be strengthened, and important measures should be taken to address clinical issues and promote the recovery of thyroid cancer patients. We should strengthen domestic multi center cooperation, expand the breadth and depth of research, and promote the prosperous development of thyroid cancer nursing.