Objective To discuss the treatment of a patient with postoperative recurrence of hepatic epithelioid hemangioendothelioma by multidisciplinary team (MDT) model. MethodsThe MDT discussion and disease diagnosis and treatment process of one patient with recurrent hepatic epithelioid angioendothelioma admitted to Zhongnan Hospital of Wuhan University in April 2021 were summarized. Results The patient was admitted to the hospital for “more than one year after operation of hepatic epithelioid hemangioendothelioma”. Two years ago, the patient’s upper abdominal CT examination showed that there was a kind of round and slightly low-density nodule shadow in the left lateral lobe of the liver, which was about 30 mm×22 mm in size, and the boundary around the nodule was clear. There was a punctate high-density shadow in the S7 segment of the liver, which was not given special treatment and was reviewed regularly. One year later, the enhanced CT examination of the liver showed that the mass in the left lateral lobe of the liver was larger than before, and multiple nodules were seen in the right lobe of the liver. After admission, MRI examination showed multiple abnormal signal foci in the liver, so atypical hemangioma-like lesions (epithelioid hemangioendothelioma may be considered) were considered. Laparoscopic left lateral lobe resection + right liver lesion resection + radiofrequency ablation of liver lesion were performed in our department, and the patient recovered well after surgery. Four months after operation, MRI reexamined and found that intrahepatic metastasis might recur, so he was re-hospitalized, and after MDT discussion, it was decided to perform laparoscopic radiofrequency ablation of liver lesions (fluorescent laparoscopy) and laparoscopic partial liver resection (fluorescent laparoscopy) again. The patient recovered well after operation, and there was no recurrence after follow-up. Conclusion For patients with postoperative recurrence of hepatic epithelioid hemangioendothelioma, a comprehensive reoperation plan is made through MDT discussion, which may bring the best prognosis to patients.