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find Author "LIU Shengchun" 1 results
  • RELATIONSHIP BETWEEN ANGIOGENESIS AND p53, c-erb B-2 ONCOGENE PROTEIN IN MALIGNANT AND PRECANCEROUS LESIONS IN BREAST

    【Abstract】Objective To investigate the association between p53, c-erb B-2 oncogene protein and angiogenesis in breast carcinoma and breast with atypical hyperplasia. Methods Immunohistochemical reaction of p53, c-erb B-2 oncogene protein was evaluated in 103 benign and malignant lesion breast paraffin-embedded specimens. The microvessel endothelial area (MEA) was quantitated by computer image analysis system (CIAS), which was immunohistochemically stained by FⅧ-RA. The relationships between p53, c-erb B-2 and MEA were analyzed. Results The MEA of p53 oncogene protein positive expression in mild atypical hyperplasia breast lesion was significantly higher than that in p53 negative (t=2.302 4,P<0.05). The MEA of p53 oncogene protein positive expression in severe atypical hyperplasia was higher than that in p53 negative (t=2.179 4,P<0.05). Moreover, no significant association between c-erb B-2 oncogene protein and MEA was observed. Conclusion p53 oncogene mutant,protein expression is significantly related to angiogenesis.

    Release date:2016-08-28 05:30 Export PDF Favorites Scan
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