Objective To explore the situation and prevention of pancreaticoduodenectomy perioperative complications. Methods The clinical data of 111 cases of pancreaticoduodenectomy were retrospectively analyzed， and the possible factor of complications was analyzed. Results There were postoperative complications in 48 patients （43.2%）， which one kind complication occurred in 25 cases， two kinds in 15 cases， and three kinds or more in 8 cases. Four cases （3.6%） died after operation. Conclusions Pancreaticoduodenectomy is a higher risk surgery in abdominal operation. Strengthen perioperative prevention and treatment are important measures to reduce morbidity and mortality after pancreaticoduodenectomy.