ObjectiveTo investigate postoperative complications and their risk factors after laparoscopic-assisted radical surgery for gastric cancer. MethodsThe clinical data of 300 patients with gastric cancer who underwent laparoscopic-assisted radical surgery in Affiliated Hospital of North Sichuan Medical College from October 2010 to October 2013 were analyzed retrospectively. Risk factors associated with postoperative complications were assessed by univariate and multivariate analysis, and survival situation of patient with postoperative complications and without postoperative complications was compared by log-rank test. ResultsOf the 300 patients, postoperative complications occurred in 51 patients (17.0%). Univariate analysis results showed that, postoperative complication was associate with age, preoperative comorbidity, American Society of Anesthesiologists (ASA) grade, operative time, and experience of surgeon (P<0.050). Logistic regression analysis results revealed that, age, preoperative comorbidity, and experience of surgeon were independent risk factors for postoperative complications (P<0.050), patients with old age, preoperative comorbidity, and underwent surgery by less experience of surgeon had higher incidence of postoperative complication. Two hundred and forty patients were followed-up for 3-35 months, with the median time of 21 months. There was no significant difference in survival situation between patients with and without postoperative complications (χ2=0.941,P=0.332). ConclusionAge, preoperative comorbidity, and experience of surgeon are independent risk factors for postoperative complicatons after laparoscopic-assisted radical surgery for gastric cancer, and the survival situation between patients with and without postoperative complications is similar.