Reports about the application of transcatheter aortic valve replacement (TAVR) for patients with aortic stenosis, whose valve sizes exceed the maximum recommended annular diameter of the largest artificial valve, is rarely in China. This paper reports an aortic stenosis patient characterized by large aortic annulus diameter with severe calcification and treated by TAVR. A comprehensive and careful operation plan was made before the operation. The anterior and posterior balloon dilatation and coronary artery protection were used during the operation. The patient was followed up for 2 years and was in stable condition.