Objective To discussion the surgical approach of laparoscopic resection of left hepatic lobe. Methods The clinical data of 86 patients with Intr- and extra-hepatic bile duct stones and liver hemangioma were analyzed retros-pectivly. Eighty-six patients underwent laparoscopic hepatectomy. Forty-nine cases underwent the left hepatic lobe resectionby the left longitudinal groove （left longitudinal groove group）， 37 cases underwent the left hepatic lobe resection by the first hepatic portal （first porta hepatis group）. The operative time， intraoperative bleeding volume， postoperative hospital stay， and postoperative complications of two kinds of operation were compared. Results The operative time and intraoperative bleeding volume of left longitudinal groove group were shorter or less than those of the first porta hepatis group 〔（142±123）min vs. （208±58）min，P＜0.05； （320.5±38.3）mL vs. （450.9±39.1）mL，P＜0.05〕. There were no statistically significant difference between the 2 groups in complication and hospitalization after operation （P＞0.05）. Conclusion The left hepatic lobe resection by the left longitudinal groove is more safe and fast.