ObjectiveTo evaluate the efficacy and safety of busprione in treatment of anxiety in patients with epilepsy. Methods122 patients with anxiety accompanied with epilepsy were collected from sep.15, 201 to June 30.2016 in the Department of Neurology in Heze Municipal Hospital, they were randomly divided into busprione group(61 cases)and alprazolam group(61 cases), and treated respectively for 6 weeks.Curative effect were evaluated by the Self-rating anxiety scale (SAS) and Hamilton anxiety scale (HAMA). Adverse reactions in two groups were recorded during the treatment. ResultsBusprione had same efficacy with alprazolam in anxiety accompanied with epilepsy, and its adverse reaction was milder. ConclusionBusprione is safe and effective for treating anxiety accompanied with epilepsy in short time.