ObjectiveTo summarize the clinical features of infection with Staphylococcus intermedius and its differential diagnosis. MethodsA clinical case of Staphylococcus intermedius infection was analyzed and Chinese literatures about Staphylococcus intermedius infection were reviewed.The literatures were derived from domestic medical journals in CNKI Digital Library and Wanfang Databases from 1998 to 2015. ResultsThe patient was a 35-year-old male.The chief complaints were cough and sputum associated with fever for three days.Chest CT scan showed cuneate and flocculent shadow with high density and unclear margin in the posterior segment of the right upper lobe and aerated bronchus sign was seen.Fuzzy shadow under the pleural was observed in the right lower lobe; On the right side of the chest, a little curved liquid density was seen.Sputum culture in Columbia blood agar plate and chocolate agar plate was done and Staphylococcus intermedius was identified.The final diagnosis of this patient was pneumonia caused by Staphylococcus intermedius.Fleroxacin 0.4 g per day was given by intravenous drip.Two weeks later, chest CT scan showed cuneate and flocculent shadow in the right upper lobe decreased obviously.Fuzzy shadow under the pleural the right lower lobe and pleural effusion on the right side of the chest disappeared.Four cases with Staphylococcus intermedius infection were reported and 3 were children.Two patients had open wound with infection.The involved organs included brain, joints, lungs, and one patient developed septicemia.Staphylococcus intermedius was identified from blood, sputum, cerebrospinal fluid, and pus from the open wound.By treatment with sensitive antibiotics three patients were cured but one patient with meningoencephalitis died of circulatory failure. ConclusionsStaphylococcus intermedius infection can occur in many organs and its clinical manifestations are dependent on the infected location.Specimen culture for pathogen is necessary and blood, sputum, cerebrospinal fluid, and pus from the open wound are optional candidates.Cultivation of Staphylococcus intermedius is similar to that of Staphylococcus aureus and should be differentiated carefully.Early treatment with high sensitive antibiotics is effective with good prognosis.