ObjectiveTo evaluate the two means of field molluscicidal effect by two different snail control drugs--new plant snail control agent luo-wei (Tea-seed distilled saponins, TDS) and 50% wettable powder of niclosamide (WPN). MethodsSuch databases as CNKI, WanFang Data, VIP and CBM databases were searched for controlled trials about TDS vs. WPN for the molluscicidal effect from their establishment to April 2014. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and assessed the methodological quality of included studies, and then meta-analysis was performed by using RevMan 5.2 software. ResultsA total of 9 studies were included. The results of meta-analysis showed that:Snails mortality rate of TDS on 7 d was lower (RR=0.96, 95%CI 0.93 to 1.00, P=0.04) than WPN and no significant difference of the snails mortality rate on 1 d or 3 d between the two groups was found by means of immersion. Meanwhile, by means of spraying, there were no significant differences on the snails mortality rate on 1 d, 3 d, 7 d, 15 d between the two groups; densities of living snails on 15 d wasn't, either. Based on GRADE system, the evidence was at level B or C. ConclusionCompared with WPN, TDS has reached the requirements of the natural source twin-screw agent field evaluation. The molluscicidal effect of TDS is better, with its large stock and low price, it is worthy to do further popularization.