Objective To investigate the association between the genetic polymorphisms of osteoprotegerin gene and bone mineral density ( BMD) in elderly patients with chronic obstructive pulmonary disease ( COPD) .Methods 178 elderly COPD patients admitted in respiratory department between January 2008 and December 2009 were recruited as a COPD group. 195 elderly healthy subjects without COPD were recruited as a control group. The subjects were all chosen from the Han population in Lanzhou city, Gansu province. Pulmonary function ( FEV1 /FVC, FEV1% pred) , body mass index ( BMI) , serum calcium ( Ca) , serum phosphate ( P) , and alkaline phosphatase ( ALP) were determined in all subjects. The OPG gene polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism ( PCR-RFLP) . BMD was examined by dual-energy X-ray absorptiometry. Results In the COPD group, the distribution frequency of AAGG, GATA, and GGTT in OPG HTT gene-linked polymorphic region G209A and T245G were 2.5%, 27.2% , and 72.3% , respectively, which in the control group were 2.2% , 26.9% , and 70.9%, respectively. The genotype distribution difference of two groups had no statistical significance ( P gt; 0.05) . There were also no statistical differences in BMI, serum Ca, serum P, serum ALP or BMD between different genotype subgroups in two groups ( P gt;0.05) . In the COPD group, the genotype distribution had no statistical significance between different BMD subgroups( P gt; 0.05) . Conclusion In the elderly patients with COPD from Han population at Lanzhou city, OPG HTT gene-linked polymorphic region and T245G gene polymorphism have no significant correlation with reduced lung function, reduced BMD and bone metabolism which are not likely to be susceptibility loci for osteoporosis in COPD patients.
ObjectiveTo explore and verify the effectiveness of task-oriented circuit therapy (TOCT) in rehabilitation training for stroke patients’ walking ability.MethodsSixty patients with stroke were selected from the Department of Neurology and Department of Rehabilitation Medicine of West China Hospital of Sichuan University from September 2019 to December 2020. By envelope method, the patients were randomly divided into the trial group and the control group, with 30 cases in each group. Both groups received routine rehabilitation treatment. The patients in the control group received conventional one-to-one rehabilitation therapy, and the patients in the trial group received TOCT training. The training lasted for 4 weeks. The patients were followed up 3 months after the training. Motor Assessment Scale (MAS) and Functional Ambulation Category Scale (FAC) were used to evaluate the walking ability of the patients before training, at the end of 4 weeks of training (after training) and at the follow-up. SF-36 health survey short form was used to evaluate the quality of life of patients before training and during follow-up.ResultsBefore training, there was no significant difference in gender, age, course of disease, stroke location, walking ability score or SF-36 score between the two groups (P>0.05). After training and at follow-up, the walking ability related scores of the two groups were improved. The trial group was better than the control group (MAS: Z=−3.220, P=0.001; Z=−4.703, P<0.001. FAC: Z=−2.447, P=0.014; Z=−3.249, P=0.001). SF-36 scores of the two groups were improved after 3 months of follow-up. The trial group was better than the control group (Z=−6.674, P<0.001). During the study period, there were no complications or adverse reactions related to rehabilitation training.ConclusionsTOCT has a significant effect on rehabilitation training of lower limb function of stroke patients. It has more advantages than conventional rehabilitation training in improving the walking ability and the quality of life of patients.