ObjectiveTo explore the imaging features of intramedullary guide rod and its influence on the alignment of the femoral prosthesis in unicompartmental knee arthroplasty (UKA). MethodsBetween August 2016 and November 2016, 50 patients (50 knees) with primary anteromedial osteoarthritis were treated with UKA by Oxford MicroPlasty minimally invasive replacement system. There were 10 males and 40 females. The age ranged from 62 to 77 years with an average of 68.8 years. Preoperative varus and flexion deformity angles were (5.22±3.46)° and (7.42±2.65)°, respectively. The knee range of motion (ROM) was (106.85±7.62)°. The Hospital for Special Surgery (HSS) score was 68.26±4.65. The angles between the femoral intramedullary guide rod and the anatomical axis of femur on the coronal and sagittal planes, the femoral component valgus/varus angle (FCVA), the femoral component posterior slope angle (FCPSA), knee varus deformity angle, and knee flexion deformity angle were measured by intra- and post-operative X-ray films. The postoperative ROM and HSS score were measured. ResultsIntraoperative X-ray films measurement showed that the lateral side angles between femoral intramedullary guide rod and femoral anatomical axis were observed on coronal plane, and the angles ranged from 0.28 to 2.06° with an average of 0.96°. While the posterior side angles were observed on sagittal plane, and the angles ranged from 0.09 to 0.48° with an average of 0.23°. The angulations (>1°) between femoral intramedullary part guide rod and outside part of the rod were confirmed in 12 cases (24%) on coronal plane. Postoperative femoral prosthesis were mild varus in 38 patients (76%). The FCVA ranged from –1.76 to 4.08° with an average of 2.21°. The FCPSA ranged from 7.12 to 13.86° with an average of 9.16°. All patients were followed up 22-26 months, with an average of 24.5 months. The incisions healed by first intention. At last follow-up, the varus and flexion deformity angles were (1.82±1.05) and (2.54 ± 1.86)°, respectively. ROM was (124.62±5.85)° and HSS score was 91.58±3.65. There were significant differences between pre- and post-operative parameters (P<0.05). No complication such as dislocation or aseptic loosening of the prosthesis occurred during the follow-up. ConclusionUKA by Oxford MicroPlasty minimally invasive replacement system can obtain accurate femoral prosthesis position with the help of intramedullary guide system, and the effectiveness is excellent.