Objective To analyze the influencing factors of delirium after endovascular aortic repair (EAR) and to provide evidence for clinical nursing and prevention of this disease. Methods Patients who underwent EAR at Fuwai Hospital, Chinese Academy of Medical Sciences from 2018 to 2019 were selected and assessed for postoperative delirium by Nursing Delirium Screening Scale (Nu-DESC). Nu-DESC score≥3 was divided into a delirium group (a case group), the non-delirium patients with the same operation and adjacent operation sequence were selected, and the ratio of 1∶4 was included in a non-delirium group (a control group). The clinical data between the two groups were compared by univariate analysis, and the significant risk factors in the univariate analysis were analyzed by multivariate logistic regression to determine the influencing factors of postoperative delirium. And stratified analysis was conducted based on thoracic endovascular aortic repair (TEVAR) and abdominal aortic repair (EVAR). Results A total of 213 patients were included in this study, including 46 patients in the case group and 167 patients in the control group. The mean age was 60.3±12.0 years, and 183 (85.9%) patients were male. Univariate analysis showed that emergency admission, preoperative neutrophil percentage, operation duration, intubation duration, and ICU duration may be associated with postoperative delirium. Multivariate analysis showed that the longer the duration of surgery and intubation, the more likely the patient was to develop delirium. In stratified analyses, the results were consistent with the general population in the TEVAR group, while no significant difference was found in the EVAR group. Conclusion The longer the operation time and tracheal intubation time are, the more prone to delirium patients undergoing TEVAR surgery are. While EVAR patients have no significant difference.