Day surgery is a new mode of diagnosis and treatment, and is greatly honoured and rewarded abroad. In China, day surgery begins rather later, but it has been gradually spread and applied in some large hospitals for its shorter hospital stay and less hospitalization cost. Day surgery management is a process including admission, operation, and discharge that should be finished within 24 hours, so the guarantee of medical quality and patient safety is principal factor of sustainable development influencing day surgery. This paper introduces the specifications for the quality and safety management of day surgery in West China Hospital of Sichuan University, to regulate and promote the application of day surgery, and further improve the medical quality and safety of day surgery.