Rehabilitation engineering is an important branch of rehabilitation medicine. Relying on combination of medical and engineering research projects to carry out the cultivation of rehabilitation medicine-engineering interdisciplinary postgraduates of medical engineering is an important way to train high-quality composite innovative talents. This article introduces the medicine-engineering interdisciplinary innovative training model of rehabilitation engineering medical workers piloted by the Department of Rehabilitation Medicine of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and the Research Institute of Rehabilitation Engineering and Technology of University of Shanghai for Science and Technology. By clarifying the objectives of medicine-engineering interdisciplinary postgraduates training, strengthening the construction of mentor teams, establishing multi-disciplinary postgraduates courses, improving teaching arrangements and apprenticeship plans, and encouraging the exchange of postgraduates with different research backgrounds, this training mode cultivates postgraduates to be guided by clinical problems in rehabilitation medicine to expand scientific research and research ideas, pomotes the transformation of research achievements and their application in clinical practice, and cultivates compound-type rehabilitation engineering research talents with post competence. The purpose is to provide a reference for the training of future composite rehabilitation engineering research talents.