Morel-Lavallée lesions manifest as a type of subcutaneous closed degloving injury, where the external violence creates a potential space between the subcutaneous tissue and the deep fascia, leading to the accumulation of fluid and the formation of infection within the cavity. The primary causes of Morel-Lavallée lesions include high-energy trauma, blunt force injuries, or compression injuries, with the lesions typically located around the greater trochanter. Due to the potential for clinical oversight, these lesions may result in complications such as infection at the fracture site. In light of these circumstances, this article provides a comprehensive review of the etiology, epidemiology, pathological mechanisms, clinical manifestations, imaging features, differential diagnosis, complications, and treatment modalities of Morel-Lavallée lesions. The aim is to enhance the awareness of trauma orthopedic surgeons regarding this injury, thereby offering insights for clinical decision-making.