ObjectiveTo investigate clinical outcomes of a new self-made nasogastric tube (NGT) fixation device. MethodsFrom January 2012 to May 2013, 76 consecutive patients with esophageal cancer who underwent esophagectomy by a same surgical group in West China Hospital were included in this study. There were 62 male and 14 female patients with their average age of 60.7 years. Clinical outcomes of the NGT fixation device were prospectively evaluated from the operation day to patients' resumption of oral intake (usually 6 days postoperatively), or the time when NGT fell off accidentally or patients asked to exit this study. The main outcomes included whether NGT fell off, and caused or increased patients' discomfort. ResultsThe operation time of the 76 patients was 192±12 minutes. Postoperatively, 1 patient died of refractory pulmonary infection and respiratory failure before further treatment was refused by the patient and relatives. All the patients completed this study. There was no NGT falling off or severe patients' discomfort. Three patients complained obvious but tolerable face compression with mild discomfort. ConclusionsThis new fixation device can effectively prevent NGT from falling off. Further clinical trial is needed to investigate its clinical value.