Objective To evaluate different clinical effects of three inflow occlusion methods in hepatectomy including pringle maneuver （Pringle group），selective portal venous exclusion （SPVE group）， and Glissonean pedicle exclusion （SGSE group）. Methods The clinical data of patients underwent the liver resection with the above liver inflow occlusion methods were retrospectively analyzed. The operation time， inflow occlusion time， amount of intraop-erative blood loss， transfusion rate， and postoperative hepatic function and complication rate were compared for each group. Results There were not significant difference of preoperative conditions，operation time， inflow occlusion time，tumor character， postoperative liver function， hospital time，and ICU time （P＞0.05）. The amount of intraoperative blood loss and rate of blood transfusion of SGSE group were significantly less （lower） than those Pringle group and SPVEgroup （P＜0.05）. In addition to the first day after operation， the AST and ALT at other time point of SPVE group and SGSE group were improved than that Pringle group （P＜0.05）， while TBIL at the third and fifth day after operation ofPringle group were improved （P＜0.05）. The complication rates of SPVE group and SGSE group were significantly lowerthan that of Pringle group （P＜0.05）. Conclusions In the similar operatin time and inflow occlusion time，Glissonean pedicle exclusion method can control the intraoperative blood loss and blood transfusion better，and can promote the patientrecovery. Besides， the inflow occlusion methods should be selected based on the practical condition of patients.