ObjectiveTo analyze the relation between marital status and prognosis of patients with colorectal cancer (CRC) in the Database from Colorectal Cancer (DACCA). MethodsThe DACCA version selected for this data analysis was updated on January 13, 2023. The data items analysis included the age, gender, marital status, tumor location, tumor property, pathological TNM (pTNM) stage, survival status, and survival time. According to the marital status, the patients were assigned into five marital statuses: the first marriage, unmarried, divorced, remarriage, and widowed groups. The overall survival (OS) and disease specific survival (DSS) of the 5 marital statuses were analyzed, and then the risk factors affecting OS and DSS were analyzed by the Cox proportional hazards regression model. ResultsA total of 7 373 data were obtained from the DACCA according to the screening conditions, of which 6 696 (90.8%) were first marriage, 108 (1.5%) were unmarried, 198 (2.7%) were divorced, 22 (0.3%) were remarriage, and 349 (4.7%) were widowed. The OS and DSS curves had no statistical differences among the CRC patients with 5 marital statuses (χ2=2.692, P=0.611; χ2=2.927, P=0.570). The 3-year cumulative overall survival rate and disease specific survival rate among the 5 marital status patients had statistical differences among the patients with five marital statuses (χ2=24.65, P<0.001; χ2=18.63, P=0.001), further pairwise comparison showed that the 3-year cumulative overall survival rate and disease specific survival rate in the CRC patients with first marriage were higher than those in the widowed patients (Z=3.36, P<0.01; Z=3.02, P<0.01). The multivariate analysis results by the Cox proportional hazards regression model did not find the marital status was associated with the OS and DSS (P>0.05). ConclusionsFrom the real-world analysis results of this study, it is found that 3-year cumulative overall survival rate and disease specific survival rate in patients with first marriage are higher as compared with widowed patients. It is necessary to pay more attention to the long-term follow-up of CRC patients in unmarried or widowed status.
ObjectiveTo analyze the relation between the marital status of patients with colorectal cancer and surgical treatment options decision-making and outcomes in the current version of the Database from Colorectal Cancer (DACCA). MethodsThe version of DACCA selected for this analysis was updated on August 31, 2022. The patients were enrolled according to the established screening criteria and then assigned to 3 groups: the unmarried, married, and divorced or widowed groups. The differences in the surgical modality decisions, surgical quality, and surgical complications among these 3 groups were analyzed. ResultsA total of 7 634 data that met the screened criteria were enrolled. It was found that the difference in the composition of the willingness to conserve anus among patients with different marital status was statistically significant (χ2=28.635, P<0.001), reflecting that the willingness to conserve anus was “strong” among unmarried and married patients, and the overall willingness to conserve anus was relatively more positive among unmarried patients, while the willingness to conserve anus was “rational” among widowed or divorced patients. No statistical differences were found in the surgical modality decisions (rectal surgery: χ2=0.493, P=0.782; colon surgery: χ2=0.213, P=0.899), including the presence of prophylactic stoma for the patient with radical resection (χ2=5.156, P=0.076）, surgical quality (H=3.452, P=0.178）, presence of surgical in-hospital complications (χ2=1.663, P=0.435), and the presence of short-term surgical complications (χ2=1.695, P=0.428). ConclusionsAnalysis of the data in DACCA reveals that there is difference in willingness to preserve anus among colorectal cancer patients with different marital status. Married and unmarried patients have stronger anal preservation intention, suggesting that clinical care and family support should be strengthened during clinical diagnosis and treatment.