Objective To investigate the surgical methods and effects of perineal Paget’s disease. Methods From January 1998 to September 2004, 20 perineal Paget’s disease cases were treated with several surgical methods. All the patients were male. Their ages ranged from 47 to 80 years. The courses of diseases ranged from 1 year to 9 years (4.7 years on average). Among them, 14 cases involved scrotums purely, 5 cases involved scrotums and penises, 1 cases involved scrotum, penis and hypogastric zone. Fifteen cases were diagnosed as having Paget’s disease through pathological exam. No metastasis was found before operation. ResultsThe wounds healed by first intention in 19 cases, the free skin graft necrosed partially in 1 case and healed by second intention after dress changing. All the patients were followed up 2 to 5 years, the contours of scrotums and penises were good. Two cases had tumor recurrence and received surgery again. Recurvation occurred in 2 cases during penis erecting，and was corrected by regional flap transplantation Conclusion The lesions like eczema in perineal reigon should be suspected as Paget’s disease, and should be biopsied earlier. Complete removal by surgery is the only effective treatment. Perineal Padget’s disease should be diagnosed and treated earlier. If the raw surfaces could not be repaired completely, flap transplantation and free skin graft should be used .The patients should be followed up closely.